Charl Bezuidenhout completed his PhD in Chemistry at Stellenbosch University (South Africa) in the Barbour research group, where he investigated host–guest dynamics in copper-based metal-organic frameworks (MOFs). He later joined the Nanoporous Materials Research Group at the University of Milano-Bicocca as a postdoctoral researcher and currently holds a researcher position in the Nanoporous Materials Research (NMR) Group.

His work focuses on the synthesis and advanced characterization of porous and responsive materials, including molecular crystals, hypercross-linked 3D polymers, and hybrid frameworks such as MOFs. He studies both their interactions with gases (for capture, separation, and sensing) and their local and global dynamical behaviour, such as framework flexibility and molecular motion.

Bezuidenhout applies a range of techniques, including in-situ X-ray diffraction (lab and synchrotron-based) under controlled atmosphere, gas sorption and sorption calorimetry, solid-state NMR simulations, and quantum mechanical modelling (DFT, molecular dynamics), to investigate the complex nature of structure–function relationships under variable conditions.

In addition to his research, Bezuidenhout is actively involved in teaching at the University of Milano-Bicocca for the didactic courses of Laboratorio di Chimica Strumentale and Chimica dei Materiali Macromolecolari within the Materials Science degree program. He is the author of 26 peer-reviewed publications in journals such as Nature Chemistry, Angewandte Chemie, and JACS, and contributes to national and European research projects focused on advanced materials for energy, sensing, and environmental applications, such as carbon capture and separation.